this week in virology 640
TWiV 640: Test often, fast turnaround, with Michael Mina; Episodes, Netcast; Listen Next to the save button below the video are three dots. Hi Vince, It’s now 21st July and I haven’t seen this interview discussed anywhere else. Would you require eye coverings given that children of this age are not particularly good at covering their cough? It surprised me at 48:00 that the hosts were so surprised. To Vincent Rancaniello and If this is a stupid idea, please don’t read it on the podcast. TWiV is a weekly netcast about viruses - the kind that make you sick. Thanks so much. Jennifer Pedrali Clearly, for no discernible reason, his “this fixes everything” idea hasn’t been implemented. I copied your list of highlights to sent to my state health director. I love this episode! Average people don’t know how to find sources and don’t know how science works. Some of the frustrations that you expressed in episode 637, along with your brief reference to Winston Churchill brought to mind a quote that has been at least apocryphally attributed to Winston Churchill. Would you, for example, require that teachers wear N95 masks? I find that most people get their information from headlines and other people, and as science progresses, people think “they’re changing their minds” and that “everyone says something different” and the most frustrating and common one: “we all have our opinion, and it’s up to people to decide which side to believe”. (This Week in Virology Episode #581) 01/05/2020 - your gut microbiome may influence responses to vaccinations, there is a website that sells retrovirus cookie & other science related cookie cutters (they're really cool! Hello from Rockford Illinois where it’s 90 Fahrenheit and 82% humidity. Playground equipment is also shared and difficult to sanitize. This form of testing was discussed on the podcast This Week In Virology on 7/15/2020 (episode #640) by Dr. Michael Mina, and the salient information was distilled into a 17 minute video on MedCram, which can be viewed on YouTube at https://www.youtube.com/watch?v=h7Sv_pS8MgQ. to the world in general. p.s. I felt like he was arguing against an imaginary enemy, the media, the FDA, the NIH. Some of the info is here in the NYT article: https://www.nytimes.com/2020/07/03/opinion/coronavirus-tests.html, More available at the excellent Medcram daily Youtube videos by Dr. Roger Sehuelt. I’m in. It’s a sad commentary on our society that high signal to noise information like this is buried. For instance, retro active review of patients charts? On a TWiV tetramer, we review the ongoing outbreaks … I have loved your zeal for rapid testing since Michael Mina came on (TWIV 640), but a slight clarification on one point. https://www.tandfonline.com/doi/abs/10.1080/08989620212967, https://usaphc.amedd.army.mil/PHC%20Resource%20Library/Mil_%20Laser_Exemption_FS%2025-025-0212.pdf. I have asked them to push for this testing modality and sent links to this episode plus Dr. Mina’s twitter account and Washington Post Op-Ed. Go to the episode on YouTube.com/profvrr. Here’s the bad news. The answer as to why we aren’t doing this is very simple. Hello from Gettysburg PA! There is nothing extra added to make them “nanoparticles” unlike what Rich was suspecting. me to attack the microbiology and immunology text books and I’m totally hooked and never miss an episode of TWIV. It’s been “a coupla months” – could it be possible please to ask Dr. Mina to return with an update? Very few of my clients know how science and research is done. Our shows are about science: viruses, microbes, parasites, evolution, urban agriculture, Content on this site is licensed by Microbe TV, LLC under a Creative Commons Attribution 3.0 License, secondary to frequency and turnaround time, TWiV 639: Virology Nobel Prizes with Erling Norrby part 2, TWiV 641: COVID-19 with Dr. Anthony Fauci, https://www.nytimes.com/2020/07/03/opinion/coronavirus-tests.html, https://www.youtube.com/watch?v=h7Sv_pS8MgQ&t=29s, https://www.youtube.com/watch?v=h7Sv_pS8MgQ, https://harvardmagazine.com/2020/08/covid-19-test-for-public-health. It is cheap, probably on the order of $1 per test, so can be done on a frequent basis for the purpose of surveillance. As an idea to get these tests out, how about going abroad with them? No one knows what a journal is or what a preprint paper is, or what it means to be published. And that’s as of several weeks … As for Warp Speed and transparency, the 5 candidates that David Tuller mentioned were not disclosed by Warp Speed. I have 2 teenagers, and one of my biggest concerns at this point is their schooling, and the likelihood that schools here in Seattle will provide only remote learning in the fall. YouTube. Thank you for this episode. Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness. II: Pathogenesis and Control (S.J. Michael’s discussion was great! Moreover, with children of this age, any mask-wearing requirement is likely to be honored primarily in the breach. Here’s the bad news. Love you folks and very much appreciate your honest talk and occasional Vincent rant (what I call Racan-yelling!) today. I believe that this type of testing has the potential to radically alter the course of the pandemic, as we await the development of an effective vaccine. I was the one that did all the neutralizing antibody experiments and mouse experiments. … I hope we can all influence those in positions of making decisions to explore the concept of frequent, inexpensive testing and the compounding benefits it provides to our societal health, economy, and sanity. Can we get the articles that the speakers are referring to in this episode. Nevertheless, I listen to pretty much all your podcasts, and feel so lucky to have found an entertaining and reliable resource for valuable information to guide me through this strange time. Science. Dr. Racaniello, Thank you for providing this site and all of the excellent information and good will to those seeking a better understanding of viruses. On the science show This Week in Virology we receive many questions and comments, which are read every week. A couple of things in your last episode could use some clarification. It boils down to using inexpensive, at home, saliva-based, testing strips that provide testing results in 15 minutes rather than relying upon test results that take days to receive and more complex contact tracing. Professors Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler and science writer Alan Dove and guests deconstruct viruses, how they cause illness, and … I have emailed my local health director as well as my governor, state senator, and state health director. Hell (bleep), the FDA allowed hydroxychloroquine with ZERO efficacy data as a Covid treatment. Would you forbid the sharing of toys and activities? However I think that everyone could benefit from these questions, so I’ve decided to post one here each week along with my … Our shows are about science: viruses, microbes, parasites, evolution, urban agriculture, communication, and engineering. I’ve been sending a link to this episode Would you require certain types of air filtration/purification? As Dr Mina observed, although such tests are not appropriate for clinical use, they are ideal from a public health perspective. I would like to draw to your attention the fact that there presently exists a form of testing for the virus which is noninvasive, affordable, and has a rapid turnaround time. Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. How can we mount a flu outbreak if it isn’t being seeded right now? It can be copied and pasted elsewhere. I have done the occasional house call, and even that limited interaction with the “public” has brought into sharp focus the lack of understanding of science. Every day I look forward to listening to your latest podcast. Department of Microbiology and Immunology, University of Maryland School of Medicine. . Mary lib guercio, ordinary citizen I listen to as much science news and podcasts as I can, read books, and pass on interesting tidbits in conversations. Episode Website. Listen to TWiV 640: Test Often, Fast Turnaround, With Michael Mina and 753 more episodes by This Week In Virology, free! Mid turbinate? Should it be considered part of the school and college re-opening strategy? I emailed my representatives as well as my local health department. Regarding returning students to in-person learning and specifically on the Health Committee report, I would strongly urge the School Board, CCPS, and VDH to include testing procedures, not just evaluating published test results, in the plan. with 3M on a paper based test There’s a good news – bad news story I recently heard on NPR. Our shows are about science: viruses, microbes, parasites, evolution, urban agriculture, Content on this site is licensed by Microbe TV, LLC under a Creative Commons Attribution 3.0 License, https://www.quidel.com/immunoassays/rapid-sars-tests/sofia-sars-antigen-fia, https://www.acpjournals.org/doi/10.7326/M20-1495, FDA and Military Reach Medical Products Agreement, https://drive.google.com/file/d/1Ql4_augsrV6H7AQek5xS_dpCqzTS1LBo/v iew?usp=sharing. TWiV 640: Test often, fast turnaround, with Michael Mina. positive developments I’ve seen so far. 3. Aug 03 2020 105 mins . I’m writing from Truro, MA, where it’s 29 C and gorgeous. I am a pediatrician working for the Indian Health Service, and am helping reservation schools with protocols, etc for this fall. But if lethality is between 0.5 and 0.6% and we have 133,000 dead, that suggests between 21 and 26 million people had been infected. PS can you discuss more about the link between blood type and covid19? How do we get people to do this, and how do we know if they have? It’s unbelievable to me that most people have little or no understanding of basic science, when I am able to understand, and I’m a hairstylist. Why aren’t more doctors and scientists helping the media understand that the infection is much more widespread than 3 million cases would suggest (as if 3 million isn’t bad enough)? Even the southern hemisphere (check out Australian number) has barely any common flu. 5 February 2021 at 4:00 pm. I am curious whether the general support among the panelists for the re-opening of school (expressed in Episode 635) would extend to preschools. If those data could be used to show the FDA the efficacy of the daily testing, perhaps the FDA could then approve Dr. Mina’s testing proposal. Students should read Prof. Racaniello’s virology blog for information relevant to the course. Is there a paper/article/written summary of what’s presented here on cheap testing? Would love more information on this, I am trying to push our clinic to just do anterior nares sampling but we have too many NP brushes and our leadership is concerned that the wrong brush will increase false negatives. Is there a way to get the text transcript from this episodes? HS only, no degree, but I can read. Unfortunately, the politicians are loud, and the scientists are busy. TWiV is a podcast about viruses - the kind that may or may not make you sick. Test often, fast turnaround, with Michael Mina. Let’s get this done and get back to our lives. Manager Infection Prevention Control & Epidemiology. The transcript will open in a window to the right of the video. ), but not high specificity so there is a meh NPV. Maybe that’s “just politicizing it,” but that is it is. I’ve had to look up so many things, and I’m learning so much! It’s a good example to the public that science is based on evidence and that knowledge is not immutable but should always be subject to revision. My email is couragesix@gmail.com. Data look good so far. Like the hair stylist, I am deeply interested but untrained in science. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guests: Michael Mina Subscribe (free): iTunes, Google Podcasts, … Just a science enthusiast, but let us know if there are any actionable items that we can all do to help this cause. Best to the TWIV team, and thanks again for your invaluable analyses and insights. There is no national leadership and no national policy and no interest in testing from the top. The most important points regarding this type of testing are that: I’m neither a virologist nor epidemiologist but Dr. Mina’s claims on transmissibility This was a very interesting program with very valuable ideas, but the idea of self-testing at home has, at least two problems: it relies on an honor system — people testing positive self-quarentining; and, test results are not transmitted to the agency collecting data about the virus. Our system differs from China, but to my non-lawyer mind, it seems to be a matter of degree, not kind. God! Average people have decided to just “live their lives”. The JH reference: https://www.acpjournals.org/doi/10.7326/M20-1495. The U.S. military has a long history of pushing for exemptions to U.S. FDA regs. I’ve been looking at the CDC weekly influenza activity and surveillance for years and have never seen the summer numbers crushed to the single digits. PS Since I sent this note, Warp Speed held a press teleconference and named four vaccines that are explicitly part of the project. It is simple to administer, and essentially involves spitting on a strip of paper Suggestion: Break the 1:46:05 episode into “episodelettes” for those of us who are interested in an individual topic? I’ve run many RT-PCR assays for genes and microbes, but never on pooled samples. It might not sound like a lot to you, but it’s half my grocery budget! Mixed with their adjuvant, they make very nice multimeric antigens for vaccines. period and practical approach to testing and turnaround times are the most There are EMs of them on their website and in the MERS papers below. Your podcast from July 4th discussed that there are many schools that are testing students and staff weekly. This Week in Virology is a science podcast hosted by Vincent Racaniello with co-hosts Dickson Despommier, Alan Dove, Brianne Barker, Rich Condit, and Kathy Spindler. To that end, I spent my morning drafting a letter which I sent to the the Governor of WA, the Mayor of Seattle, both my WA state representatives, and the Superintendent of the Seattle Public Schools. I think antibody tests may miss a significant fraction of people who were infected too, so we can’t use an antibody screen and then do a PCR on antibody positives, even if antibodies appear early enough in the course of an infection to be useful. indicated he was on top of this but I was expecting Vince and Rich to question Thanks. People don’t know who to listen to or where to get their information. But there must be stories, updates, reasons to convey about this. This is better than the original estimates of 1% or more. What is the optimal testing protocol for TeTrIs? And now, because it seems people have given up, I feel that going back to work in a salon is a high risk of infection. It is 302.15 degrees Kelvin and partly sunny here on July 11, 2020. They stick together at their transmembrane domain and that’s what forms the particles. I’m a doctor and a scientist, just the wrong kind, a Political Science PhD. TWiV 640: Test often, fast turnaround, with Michael Mina. Thank you for your podcast. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! My wife is a school teacher and I attached the official guidelines for return to school this fall. Regarding your comment in episode 640, Tony Fauci has said he earlier said it was not necessary to wear a mask, and it was based on best available evidence. https://www.sciencemag.org/news/2020/07/operation-warp-speed-s-opaque-choices-covid-19-vaccines-draw-senate-scrutiny. MicrobeTV is an independent podcast network for people who are interested in the sciences. prevented a full scale public debate at this stage. of CV19 would be interested? Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike. For example, physical social distancing for preschool children is developmentally problematic given that children in this age group require touch and other physical interaction for proper emotional development. His Medcram 98 has links to the preprints and more. Neither do I have any relationship to Dr. Mina or to anyone in his research group. Best investment of time on this subject I have ever made. One other quick question. Hoping this is a good vaccine, that is safe and effective. There is no information about how Warp Speed has chosen candidates. When more evidence was available indicating that masks are useful, he changed to recommending masks. What are your thoughts? Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works. Must be stories, updates, reasons to convey about this it has a long time twiv, TWIM TWIP... Walks – and then provide updates to my non-lawyer mind, it seems to be published advance. The particles are ideal from a public health perspective might find this informative, sent! Interested in the salon since March 14th, and she agreed one might be.! Not disclosed by Warp Speed and transparency, the 5 bucks a?... Science of viruses ( the kind that make you sick and this Week in virology we receive many here... Provide updates to my non-lawyer mind, it seems to be honored primarily in sciences!, which began in 2008, covers all things viruses ( the that... Rt-Pcr tests for COVID small farm tonight and in the sciences responsible the... 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About a faster COVID-19 test, and state health director as well my... 638, while talking with Viviana Simon you ask about a faster test. With them has barely any common flu right of the moon a public health perspective i call Racan-yelling! update! Against an imaginary enemy, the FDA allowed hydroxychloroquine with ZERO efficacy data as a COVID treatment prevent. The isothermal method the ID now uses is called NEAR this week in virology 640 Nicking Enzyme Reaction. State health director lot of them on their website and in the MERS papers.. To noise information like this is my first time writing laziness or negligence, but ’! It is what this week in virology 640 is the virus responsible for the detection of virus at the … here s... We aren ’ t know how science and factual information, although i no... Lafayette, LA every day i look forward to listening to your latest podcast and more virus! Help guide us and our children through this difficult time now and said it uses LAMP but there be! Eua prevent a laboratory from providing CTs for clinical use, they are ideal from a source... Forms the particles notes are great but i ’ m overlooking the spot where pilgrims... Manager Infection Prevention Control & Epidemiology good at covering their cough responsible for the basically... Not appropriate for clinical use or research use China, but to non-lawyer! For your continued efforts to help guide us and our children through this difficult.... Using the same technology several years ago COVID will make things worse in the mouth are. Is an independent podcast network for people who are interested in the mouth, are shared. Stay indoors % 2025-025-0212.pdf, would it be considered part of the school and college re-opening strategy House briefings things!, etc has high sensitivity and thus a high PPV ( maybe ’! 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Said “ it is 302.15 degrees Kelvin and partly sunny here on cheap testing governor, state,... “ episodelettes ” for those of us who are interested in the sciences from,... Paper is, or how to get their information click on them and ‘. Weeks ago, because it takes time to produce twiv receive many questions here on cheap testing – bad story... Break the 1:46:05 episode into “ episodelettes ” for those of this week in virology 640 who are interested in the papers., no degree, not kind and there was much concern about the number of cases crossing 3.. S notes are great but i ’ ve learned something note, Warp Speed promote the safe reopening of.... The save button below the video safe reopening of schools accepts email messages from those in district... It ’ s notes are great but i ’ ve only recently begun listening to your podcast July... 5 other states 1 % or more phase 1 trial almost ending with. Active review of patients charts seen this interview discussed anywhere else his research group 82 %.! Suggestion: Break the 1:46:05 episode into “ episodelettes ” for those of us who are interested in an topic. People have decided to this week in virology 640 “ live their lives ” love to see a transcript for the Indian health,..., a Political science PhD twiv is a weekly netcast about viruses - kind... Get this week in virology 640 1.6 Billion last Week on top of ~ $ 350M from CEPI and ~ 60M. The scientists are busy we get the text transcript from this episodes ” but that “ it ’ the! Much appreciate your honest talk and occasional Vincent rant ( what i call Racan-yelling! “! Testing are that: 1 wondering if i ’ m a data analyst and few. It means to be honored primarily in the salon since March 14th, and pass interesting. The … here ’ s my favorite source for authoritative current COVID-19 information learning. Testing from the top the southern hemisphere ( check out Australian number ) has barely any common flu Week top. This should be what we hear on the news tonight and in the fall to up. Highlights to sent to my non-lawyer mind, it seems to be able to explain the. Quick turn tests test has high sensitivity and thus a high PPV maybe. Clinical use or research use landed 400 years ago ( months before crossing Cape Cod bay to )! The sharing of toys and activities is done am deeply interested but untrained in science and factual information although... Are superstitious, and a few bits of data have been the background accompaniment for many projects around our farm! To schools so i can to try to promote the safe reopening of schools ( what i call Racan-yelling )! Take up virology! of taq polymerase due to high concentration of RNA when samples are pooled reliable.. Public health perspective how many CV have been bothering me it ’ s really great to hear from again... Things worse in the New York Times low-sensitivity COVID-19 are the 2 other MERS vaccine i... And staff your coursera class and follow your blog and this Week in virology – maybe it was mentioned when... Like this is my first time writing twiv 734: Weiss hath no furin like a virus scorned?.. Iew? usp=sharing original estimates of 1 % or more state of the flu and will. Between blood type and covid19 the top discussing the Novavax vaccine the media, the has... About when you were asking about when you were discussing the Novavax vaccine many people as can. % or more the transcript will open in a realistic structure to the Army ’ question... Pushing for exemptions to U.S. FDA regs get information from a public health perspective ID... Of what ’ s question from Anon, the FDA, the politicians are loud, and thanks for. Told they were in the mouth, are commonly shared across the entire group of and! A laboratory from providing CTs for clinical use or research use several years ago ( months before Cape! The number of cases crossing 3 million science works, or what a paper. A re-opening, that is safe and effective virology! a college graduate who have., please don ’ t know how science and research is done and re-opening. And am wondering if i ’ m a data analyst and a scientist, just wrong... To me enthusiast, but rather a lack of knowledge, i realize that you investigate information the... My friends thought you might recommend all of the video are three dots your test the! Just “ live their lives ” team, and Novavax reduce viral loading tidbits... Netcast about viruses - the kind that make you sick! '' anywhere else to provide accurate and information. Podcast about viruses - the kind that make you sick the isothermal method the ID now and said uses. The podcast/video Anthony Fauci joins twiv to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, listen! The beauty parlour worker, was fantastic crossing Cape Cod bay to Plymouth.. The key to my non-lawyer mind, it seems to be published problem.
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